The Life Cycle of Trypanosoma Brucei in the Rat and in Rat Plasma.
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Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats
The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...
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متن کاملTrypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activity.
A trypsin-like serine peptidase activity, levels of which correlate with blood parasitemia levels, is present in the plasma of rats acutely infected with Trypanosoma brucei brucei. Antibodies to a trypanosome peptidase with a trypsin-like substrate specificity (oligopeptidase B [OP-Tb]) cross-reacted with a protein in the plasma of trypanosome-infected rats on a Western blot. These antibodies a...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 1 10 شماره
صفحات -
تاریخ انتشار 2005